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>   首页   >   产品   >   一抗   >   神经科学   >   MAGI2 Antibody (C-term)   

MAGI2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MAGI2 Antibody (C-term) AP21243b
    All lanes : Anti-MAGI2 Antibody (C-term) at 1:2000 dilution Lane 1: mouse brain lysates Lane 2: rat brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 159 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q86UL8
Reactivity Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 158754 Da
Additional info
Gene ID 9863
Other Names Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, Atrophin-1-interacting protein 1, AIP-1, Atrophin-1-interacting protein A, Membrane-associated guanylate kinase inverted 2, MAGI-2, MAGI2, ACVRINP1, AIP1, KIAA0705
Target/Specificity This MAGI2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1123-1156 amino acids from the C-terminal region of human MAGI2.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAGI2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGI2
Synonyms ACVRINP1, AIP1, KIAA0705
Function Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
Cellular Location Cytoplasm. Late endosome. Cell junction, synapse, synaptosome Cell membrane; Peripheral membrane protein. Note=Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes (By similarity).
Tissue Location Specifically expressed in brain.
Research Areas

BACKGROUND

Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.

REFERENCES

Wood J.D.,et al.Mol. Cell. Neurosci. 11:149-160(1998).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Wu X.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:4233-4238(2000).

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