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>   首页   >   产品   >   一抗   >   神经科学   >   Mouse Mertk Antibody (C-term)   

Mouse Mertk Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Mouse Mertk Antibody (C-term) AP21205b
    All lanes : Anti-Mertk Antibody (C-term) at 1:2000 dilution Lane 1: mouse kidney lysates Lane 2: mouse liver lysates Lane 3: NIH/3T3 whole cell lysates Lane 4: rat kidney lysates Lane 5: rat liver lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 110 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - Mouse Mertk Antibody (C-term) AP21205b
    Anti-Mertk Antibody (C-term) at 1:1000 dilution + mouse spleen lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 110 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q60805
Reactivity Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 110157 Da
Additional info
Gene ID 17289
Other Names Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mertk, Mer
Target/Specificity This Mouse Mertk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 946-980 amino acids from the C-terminal region of mouse Mertk.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Mertk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mertk
Synonyms Mer
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed predominantly in the hematopoietic lineages: macrophages, NK cells, NKT cells, dendritic cells and platelets.
Research Areas

BACKGROUND

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

REFERENCES

Graham D.K.,et al.Oncogene 10:2349-2359(1995).
Dowds C.A.,et al.Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
Lu Q.,et al.Nature 398:723-728(1999).
Georgescu M.M.,et al.Mol. Cell. Biol. 19:1171-1181(1999).
Behrens E.M.,et al.Eur. J. Immunol. 33:2160-2167(2003).

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