|Application ||WB, IHC, FC, E|
|Calculated MW||20324 Da|
|Other Names||Myelin-associated neurite-outgrowth inhibitor, Mani, p20, FAM168B, KIAA0280L, MANI|
|Target/Specificity||This FAM168B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 105-139 amino acids from the Central region of human FAM168B.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAM168B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity).|
|Cellular Location||Cytoplasm, perinuclear region. Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Expressed in neuronal cell bodies and axonal fibers.|
|Tissue Location||Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level) Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level)|
Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity).
Mishra M.,et al.J. Cell. Mol. Med. 15:1713-1725(2011).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Mishra M.,et al.FEBS Lett. 586:3018-3023(2012).