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>   首页   >   产品   >   一抗   >   精选抗体   >   G蛋白偶联受体抗体(GPCR)   >   CNR2 Antibody (N-term)   

CNR2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CNR2 Antibody (N-term) AP21180a
    Anti-CNR2 Antibody (N-term) at 1:2000 dilution + human brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 40 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P34972
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 39681 Da
Additional info
Gene ID 1269
Other Names Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B
Target/Specificity This CNR2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-53 amino acids from the N-terminal region of human CNR2.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCNR2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNR2
Synonyms CB2A, CB2B
Function Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note=Localizes to apical dendrite of pyramidal neurons
Tissue Location Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes
Research Areas

BACKGROUND

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

REFERENCES

Munro S.,et al.Nature 365:61-65(1993).
Liu Q.-R.,et al.Genes Brain Behav. 8:519-530(2009).
Bruess M.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Saravanan T.,et al.Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.

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