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>   首页   >   产品   >   一抗   >   精选抗体   >   CBX7 Antibody (C-term)   

CBX7 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CBX7 Antibody (C-term) AP21163a
    Anti-CBX7 Antibody (C-term) at 1:1000 dilution + HepG2 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - CBX7 Antibody (C-term) AP21163a
    Anti-CBX7 Antibody (C-term) at 1:500 dilution + SK-N-MC whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O95931
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 28341 Da
Additional info
Gene ID 23492
Other Names Chromobox protein homolog 7, CBX7
Target/Specificity This CBX7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 168-201 amino acids from the C-terminal region of human CBX7.
Dilution WB~~1:500
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBX7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX7
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Cellular Location Nucleus
Research Areas

BACKGROUND

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

REFERENCES

Dunham I.,et al.Nature 402:489-495(1999).
Gil J.,et al.Nat. Cell Biol. 6:67-72(2004).
Bezsonova I.,et al.Biochemistry 48:10542-10548(2009).
Maertens G.N.,et al.PLoS ONE 4:E6380-E6380(2009).
Li Q.,et al.PLoS ONE 5:E13732-E13732(2010).

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