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>   首页   >   产品   >   一抗   >   精选抗体   >   Mouse Epc1 Antibody (Center)   

Mouse Epc1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Mouse Epc1 Antibody (Center) AP21161a
    Anti-Mouse Epc1 Antibody (Center) at 1:2000 dilution + mouse brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size :90 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8C9X6
Reactivity Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 90411 Da
Additional info
Gene ID 13831
Other Names Enhancer of polycomb homolog 1, Epc1
Target/Specificity This Mouse Epc1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 425-460 amino acids from the Central region of Mouse Epc1.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Epc1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Epc1
Function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed in adult brain, heart, kidney, liver, lung, skeletal muscle and testis
Research Areas

BACKGROUND

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).

REFERENCES

Stankunas K.,et al.Development 125:4055-4066(1998).
Carninci P.,et al.Science 309:1559-1563(2005).

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