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>   首页   >   产品   >   一抗   >   心血管   >   (Mouse) Epha1 Antibody (Center)   

(Mouse) Epha1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - (Mouse) Epha1 Antibody (Center) AP21159a
    Anti-(Mouse) Epha1 Antibody (Center) at 1:2000 dilution + A549 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 109 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q60750
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 108578 Da
Additional info
Gene ID 13835
Other Names Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk
Target/Specificity This mouse Epha1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 453-487 amino acids from the Central region of mouse Epha1.
Dilution WB~~1:2000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Epha1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Epha1
Synonyms Esk
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Preferentially expressed in epithelial cells including skin, kidney, liver and thymus
Research Areas

BACKGROUND

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

REFERENCES

Coulthard M.G.,et al.Growth Factors 18:303-317(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Lickliter J.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:145-150(1996).
Duffy S.L.,et al.Genesis 46:553-561(2008).

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