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>   首页   >   产品   >   一抗   >   神经科学   >   (Mouse) Sox2 Antibody (N-term)   

(Mouse) Sox2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - (Mouse) Sox2 Antibody (N-term) AP21154a
    Anti-(Mouse) Sox2 Antibody (N-term) at 1:1000 dilution + NCCIT whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size :34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P48432
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 34454 Da
Additional info
Gene ID 20674
Other Names Transcription factor SOX-2, Sox2, Sox-2
Target/Specificity This Mouse Sox2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 34-68 amino acids from the N-terminal region of mouse Sox2.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Sox2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sox2
Synonyms Sox-2
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:17097055}
Tissue Location Expressed in the brain and retina. A very low level expression is seen in the stomach and lung. Expressed in developing urogenital ridge
Research Areas

BACKGROUND

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

REFERENCES

Yuan H.,et al.Genes Dev. 9:2635-2645(1995).
Yuan H.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
Collignon J.,et al.Development 122:509-520(1996).
Tsuruzoe S.,et al.Biochem. Biophys. Res. Commun. 351:920-926(2006).
Takahashi K.,et al.Cell 126:663-676(2006).

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