注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 二抗
  • IVD原料
  • 多肽
  • 蛋白
  • 裂解液
  • 免疫试剂盒&组化产品
  • 代理产品
  • 分子生物学产品
>   首页   >   产品   >   一抗   >   癌症   >   PDGFD Antibody   

PDGFD Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PDGFD Antibody AP21138a
    Western blot analysis of lysate from mouse kidney tissue lysate, using PDGFD Antibody(Cat. #AP21138a). AP21138a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9GZP0
Reactivity Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 42848 Da
Additional info
Gene ID 80310
Other Names Platelet-derived growth factor D, PDGF-D, Iris-expressed growth factor, Spinal cord-derived growth factor B, SCDGF-B, Platelet-derived growth factor D, latent form, PDGFD latent form, Platelet-derived growth factor D, receptor-binding form, PDGFD receptor-binding form, PDGFD, IEGF, SCDGFB
Target/Specificity This PDGFD antibody is generated from a rabbit immunized with a recombinant protein of human PDGFD.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDGFD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDGFD
Synonyms IEGF, SCDGFB
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
Cellular Location Secreted. Note=Released by platelets upon wounding
Tissue Location Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
Research Areas

BACKGROUND

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).

REFERENCES

Hamada T.,et al.Biochem. Biophys. Res. Commun. 280:733-737(2001).
Bergsten E.,et al.Nat. Cell Biol. 3:512-516(2001).
LaRochelle W.J.,et al.Nat. Cell Biol. 3:517-521(2001).
Wistow G.,et al.Mol. Vis. 8:185-195(2002).
Liu B.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.

FeedBack

终于等到您。感谢您使用ABGENT(百奇生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-69369088-1015 market.abgent@wuxiapptec.com.


我要评价