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>   首页   >   产品   >   一抗   >   细胞生物学   >   Mouse Frk Antibody (C-term)   

Mouse Frk Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Mouse Frk Antibody (C-term) AP21130a
    Western blot analysis of lysate from mouse lung tissue lysate, using Frk Antibody (C-term)(Cat. #AP21130a). AP21130a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q922K9
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58844 Da
Additional info
Gene ID 14302
Other Names Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, Frk, Bsk, Iyk
Target/Specificity This Mouse Frk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 476-509 amino acids from the C-terminal region of mouse Frk.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Frk Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Frk
Synonyms Bsk, Iyk
Function Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Tissue Location Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung
Research Areas

BACKGROUND

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).

REFERENCES

Thuveson M.,et al.Biochem. Biophys. Res. Commun. 209:582-589(1995).
Oberg-Welsh C.,et al.Gene 152:239-242(1995).
Carninci P.,et al.Science 309:1559-1563(2005).
Chandrasekharan S.,et al.Mol. Cell. Biol. 22:5235-5247(2002).
Welsh M.,et al.Biochem. J. 382:261-268(2004).

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