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>   首页   >   产品   >   一抗   >   其他   >   PRDM14 Antibody (N-term)   

PRDM14 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - PRDM14 Antibody (N-term) AP21051a
    Western blot analysis of lysate from HepG2 cell line, using PRDM14 Antibody (N-term)(Cat. #AP21051a). AP21051a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9GZV8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 64062 Da
Additional info
Gene ID 63978
Other Names PR domain zinc finger protein 14, 211-, PR domain-containing protein 14, PRDM14
Target/Specificity This PRDM14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 128-163 amino acids from the N-terminal region of human PRDM14.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRDM14 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDM14
Function Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
Cellular Location Nucleus.
Tissue Location Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level)
Research Areas

BACKGROUND

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.

REFERENCES

Yang X.-H.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nishikawa N.,et al.Cancer Res. 67:9649-9657(2007).
Chia N.Y.,et al.Nature 468:316-320(2010).
Rigbolt K.T.,et al.Sci. Signal. 4:RS3-RS3(2011).

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