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>   首页   >   产品   >   一抗   >   发育生物学   >   NACC1 Antibody (Center)   

NACC1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - NACC1 Antibody (Center) AP21031a
    Anti-NACC1 Antibody (Center)at 1:1000 dilution + human brain lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 57 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - NACC1 Antibody (Center) AP21031a
    Western blot analysis of lysate from mouse kidney tissue, using NACC1 Antibody (Center)(Cat. #AP21031a). AP21031a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96RE7
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57258 Da
Additional info
Gene ID 112939
Other Names Nucleus accumbens-associated protein 1, NAC-1, BTB/POZ domain-containing protein 14B, NACC1, BTBD14B, NAC1
Target/Specificity This NACC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 324-358 amino acids from the Central region of human NACC1.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNACC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NACC1
Synonyms BTBD14B, NAC1
Function Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Cellular Location Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation.
Tissue Location Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
Research Areas

BACKGROUND

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

REFERENCES

Cha X.Y.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Nakayama K.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:18739-18744(2006).
Nakayama K.,et al.Cancer Res. 67:8058-8064(2007).
Davidson B.,et al.Hum. Pathol. 38:1030-1036(2007).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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