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>   首页   >   产品   >   一抗   >   发育生物学   >   (Mouse) Sox17 Antibody (C-term)   

(Mouse) Sox17 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - (Mouse) Sox17 Antibody (C-term) AP21025c
    Western blot analysis of lysate from LNCaP cell line, using Sox17 Antibody (C-term)(Cat. #AP21025c). AP21025c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q61473
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44646 Da
Additional info
Gene ID 20671
Other Names Transcription factor SOX-17, Sox17, Sox-17
Target/Specificity This (Mouse) Sox17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 376-409 amino acids from the C-terminal region of mouse Sox17.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Sox17 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sox17
Synonyms Sox-17
Function Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:20802155}
Tissue Location Testis. Detected in lung.
Research Areas

BACKGROUND

Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity.

REFERENCES

Kanai Y.,et al.J. Cell Biol. 133:667-681(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Layfield R.,et al.Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
Kanai-Azuma M.,et al.Development 129:2367-2379(2002).
Kim I.,et al.Cell 130:470-483(2007).

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