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>   首页   >   产品   >   一抗   >   神经科学   >   Mouse Hes1 Antibody (C-term)   

Mouse Hes1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Mouse Hes1 Antibody (C-term) AP21019c
    Western blot analysis of lysate from mouse kidney tissue lysate, using Hes1 Antibody (C-term)(Cat. #AP21019c). AP21019c was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P35428
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29749 Da
Additional info
Gene ID 15205
Other Names Transcription factor HES-1, Hairy and enhancer of split 1, Hes1, Hes-1
Target/Specificity This Mouse Hes1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of Mouse Hes1.
Dilution WB~~1:500
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Hes1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Hes1
Synonyms Hes-1
Function Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
Cellular Location Nucleus.
Tissue Location Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds
Research Areas

BACKGROUND

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).

REFERENCES

Takebayashi K.,et al.J. Biol. Chem. 269:5150-5156(1994).
Grbavec D.,et al.Eur. J. Biochem. 258:339-349(1998).
Bae S.-K.,et al.Development 127:2933-2943(2000).

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