|Application ||WB, E|
|Calculated MW||25851 Da|
|Other Names||Extracellular superoxide dismutase [Cu-Zn], EC-SOD, SOD3|
|Target/Specificity||This SOD3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 186-219 amino acids from the C-terminal region of human SOD3.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.|
|Cellular Location||Secreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium|
|Tissue Location||Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid|
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Hjalmarsson K.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6340-6344(1987).
Folz R.J.,et al.Genomics 22:162-171(1994).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Adachi T.,et al.Free Radic. Biol. Med. 13:205-210(1992).
Nozik-Grayck E.,et al.Int. J. Biochem. Cell Biol. 37:2466-2471(2005).