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>   首页   >   产品   >   一抗   >   心血管   >   Mouse Ephb4 Antibody (C-term)   

Mouse Ephb4 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Mouse Ephb4 Antibody (C-term) AP20989c
    Western blot analysis of lysate from PC-3 cell line, using Mouse Ephb4 Antibody (C-term)(Cat. #AP20989c). AP20989c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P54761
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108848 Da
Additional info
Gene ID 13846
Other Names Ephrin type-B receptor 4, Developmental kinase 2, mDK-2, Hepatoma transmembrane kinase, Tyrosine kinase MYK-1, Ephb4, Htk, Mdk2, Myk1
Target/Specificity This Mouse Ephb4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 967-1000 amino acids from the C-terminal region of mouse Ephb4.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Ephb4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ephb4
Synonyms Htk, Mdk2, Myk1
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in various organ systems, including lung, liver, kidney, intestine, muscle and heart
Research Areas

BACKGROUND

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

REFERENCES

Ciossek T.,et al.Oncogene 11:2085-2095(1995).
Andres A.-C.,et al.Oncogene 9:1461-1467(1994).
Wilson M.D.,et al.Nucleic Acids Res. 29:1352-1365(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Gerety S.S.,et al.Mol. Cell 4:403-414(1999).

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