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>   首页   >   产品   >   一抗   >   心血管   >   Mouse Myocd Antibody (C-term)   

Mouse Myocd Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Mouse Myocd Antibody (C-term) AP20988c
    Anti-Myocd Antibody (Cterm) at 1:2000 dilution + C2C12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 101 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - Mouse Myocd Antibody (C-term) AP20988c
    Western blot analysis of lysate from mouse C2C12 cell line, using Myocd Antibody (C-term)(Cat. #AP20988c). AP20988c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8VIM5
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 101400 Da
Additional info
Gene ID 214384
Other Names Myocardin, Basic SAP coiled-coil transcription activator 2, SRF cofactor protein, Myocd, Bsac2, Mycd, Srfcp
Target/Specificity This Mouse Myocd antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 743-777 amino acids from the C-terminal region of Mouse Myocd.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Myocd Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Myocd
Synonyms Bsac2, Mycd, Srfcp
Function Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.
Cellular Location Nucleus speckle Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei
Tissue Location Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues. Isoform 3 is the most abundant isoform in the heart from embryo to adult.
Research Areas

BACKGROUND

Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.

REFERENCES

Wang D.-Z.,et al.Cell 105:851-862(2001).
Wang D.-Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002).
Ueyama T.,et al.Mol. Cell. Biol. 23:9222-9232(2003).
Sawada T.,et al.Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
Du K.L.,et al.Mol. Cell. Biol. 23:2425-2437(2003).

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