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>   首页   >   产品   >   一抗   >   癌症   >   NCOA2 Antibody (C-term)   

NCOA2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - NCOA2 Antibody (C-term) AP20987c
    Western blot analysis of lysates from human liver, mouse liver tissue lysate (from left to right), using NCOA2 Antibody (C-term)(Cat. #AP20987c). AP20987c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q15596
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 159157 Da
Additional info
Gene ID 10499
Other Names Nuclear receptor coactivator 2, NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2, NCOA2, BHLHE75, SRC2, TIF2
Target/Specificity This NCOA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1169-1203 amino acids from the C-terminal region of human NCOA2.
Dilution WB~~1:500-1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNCOA2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCOA2
Synonyms BHLHE75, SRC2, TIF2
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK- ARNTL/BMAL1 heterodimer (By similarity).
Cellular Location Nucleus.
Research Areas

BACKGROUND

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.

REFERENCES

Voegel J.J.,et al.EMBO J. 15:3667-3675(1996).
Carapeti M.,et al.Blood 91:3127-3133(1998).
Voegel J.J.,et al.EMBO J. 17:507-519(1998).
Fryer C.J.,et al.Nature 393:88-91(1998).
Carrero P.,et al.Mol. Cell. Biol. 20:402-415(2000).

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