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>   首页   >   产品   >   一抗   >   干细胞   >   (Mouse) Ihh Antibody (C-term)   

(Mouse) Ihh Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - (Mouse) Ihh Antibody (C-term) AP20944c
    Western blot analysis of lysates from human kidney and rat liver tissue (from left to right), using Ihh Antibody (C-term)(Cat. #AP20944c). AP20944c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P97812
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 45485 Da
Additional info
Gene ID 16147
Other Names Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, Ihh
Target/Specificity This Mouse Ihh antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 397-430 amino acids from the C-terminal region of mouse Ihh.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Ihh Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Ihh
Function Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
Cellular Location Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note=The N-terminal peptide remains associated with the cell surface. Cell membrane.
Tissue Location In the embryo, detected in the developing gut, the growth zone of cartilage of developing long bones, epithelium and urogenital sinus. In the adult kidney, found in proximal convoluted and proximal straight tubule
Research Areas

BACKGROUND

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

REFERENCES

Valentini R.P.,et al.J. Biol. Chem. 272:8466-8473(1997).
Echelard Y.,et al.Cell 75:1417-1430(1993).
St Jacques B.,et al.Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
Chang D.T.,et al.Development 120:3339-3353(1994).

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