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>   首页   >   产品   >   一抗   >   心血管   >   Mouse Epha1 Antibody (N-term)   

Mouse Epha1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Mouse Epha1 Antibody (N-term) AP20929b
    Western blot analysis of lysates from mouse kidney, mouse lung, mouse skin tissue (from left to right), using Epha1 Antibody (N-term)(Cat. #AP20929b). AP20929b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q60750
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108578 Da
Additional info
Gene ID 13835
Other Names Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk
Target/Specificity This Mouse Epha1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 70-105 amino acids from the N-terminal region of Mouse Epha1.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Epha1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Epha1
Synonyms Esk
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Preferentially expressed in epithelial cells including skin, kidney, liver and thymus
Research Areas

BACKGROUND

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

REFERENCES

Coulthard M.G.,et al.Growth Factors 18:303-317(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Lickliter J.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:145-150(1996).
Duffy S.L.,et al.Genesis 46:553-561(2008).

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