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>   首页   >   产品   >   一抗   >   发育生物学   >   FOXN4 Antibody (Center)   

FOXN4 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FOXN4 Antibody (Center) AP20908a
    Western blot analysis of lysate from human brain tissue lysate, using FOXN4 Antibody (Center)(Cat. #AP20908a). AP20908a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96NZ1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55215 Da
Additional info
Gene ID 121643
Other Names Forkhead box protein N4, FOXN4
Target/Specificity This FOXN4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 314-349 amino acids from the Central region of human FOXN4.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOXN4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXN4
Function Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089}
Research Areas

REFERENCES

Scherer S.E.,et al.Nature 440:346-351(2006).
Danilova N.,et al.Brain Res. Dev. Brain Res. 153:115-119(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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