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>   首页   >   产品   >   一抗   >   癌症   >   Mouse Erbb2 Antibody (P1142)   

Mouse Erbb2 Antibody (P1142)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Mouse Erbb2 Antibody (P1142) AP20907a
    Western blot analysis of lysate from mouse kidney tissue lysate, using Erbb2 Antibody (P1142)(Cat. #AP20907a). AP20907a was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
  • 1 - Mouse Erbb2 Antibody (P1142) AP20907a
    Western blot analysis of lysates from mouse lung, mouse ovary tissue lysate (from left to right), using Erbb2 Antibody (P1142)(Cat. #AP20907a). AP20907a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P70424
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 138579 Da
Additional info
Gene ID 13866
Other Names Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu
Target/Specificity This Mouse Erbb2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1176 amino acids from the human region of Mouse Erbb2.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Erbb2 Antibody (P1142) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Erbb2
Synonyms Kiaa3023, Neu
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus
Tissue Location Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers
Research Areas

BACKGROUND

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).

REFERENCES

Okazaki N.,et al.DNA Res. 10:167-180(2003).
Lim J.,et al.Endocrinology 138:1328-1337(1997).
Moscoso L.M.,et al.Dev. Biol. 172:158-169(1995).
Muthuswamy S.K.,et al.Oncogene 11:271-279(1995).
Jaulin-Bastard F.,et al.J. Biol. Chem. 276:15256-15263(2001).

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