注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 二抗
  • IVD原料
  • 多肽
  • 蛋白
  • 裂解液
  • 免疫试剂盒&组化产品
  • 代理产品
  • 分子生物学产品
>   首页   >   产品   >   一抗   >   精选抗体   >   (Mouse) Mlf1 Antibody (Center)   

(Mouse) Mlf1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - (Mouse) Mlf1 Antibody (Center) AP20887a
    Western blot analysis of lysates from human skeletal muscle, mouse testis tissue lysate (from left to right), using Mlf1 Antibody (Center)(Cat. #AP20887a). AP20887a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9QWV4
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30432 Da
Additional info
Gene ID 17349
Other Names Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1, Mlf1, Hls7
Target/Specificity This (Mouse) Mlf1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 91-126 amino acids from the Central region of (Mouse) Mlf1.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(Mouse) Mlf1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mlf1
Synonyms Hls7
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Cellular Location Cytoplasm. Nucleus. Note=In non- hematopoietic cells, resides primarily in the cytoplasm with some punctate nuclear localization. Shuttles between the cytoplasm and nucleus. In hematopoietic cells, located preferentially in the nucleus
Tissue Location Highly expressed in skeletal muscle, heart, testis. Also found in lung, but not in spleen, thymus, bone marrow, liver and kidney.
Research Areas

BACKGROUND

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

REFERENCES

Hitzler J.K.,et al.Am. J. Pathol. 155:53-59(1999).
Williams J.H.,et al.EMBO J. 18:5559-5566(1999).
Lim R.,et al.J. Biol. Chem. 277:40997-41008(2002).
Winteringham L.N.,et al.Oncogene 23:5105-5109(2004).
Winteringham L.N.,et al.J. Biol. Chem. 281:38791-38800(2006).

FeedBack

终于等到您。感谢您使用ABGENT(百奇生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-69369088-1015 market.abgent@wuxiapptec.com.


我要评价