|Application ||WB, E|
|Calculated MW||144875 Da|
|Other Names||Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, Insrr, Irr|
|Target/Specificity||This Mouse Insrr antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1295-1289 amino acids from the C-terminal region of human Mouse Insrr.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Insrr Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the islets as well as in pancreatic beta-cells.|
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Hirayama I.,et al.Diabetes 48:1237-1244(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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Deyev I.E.,et al.Cell Metab. 13:679-689(2011).