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CD44 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CD44 Antibody (C-term) AP20764c
    All lanes : Anti-CD44 Antibody at 1:2000 dilution (upper) Lane 1: Hela Lane 2: Hela-CD44-Knock out Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 82 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - CD44 Antibody (C-term) AP20764c
    Western blot analysis of lysates from Hela, PC-3, HT-1080 cell line (from left to right), using CD44 Antibody (C-term)(Cat. #AP20764c). AP20764c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P16070
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 81538 Da
Additional info
Gene ID 960
Other Names CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I, CD44, CD44, LHR, MDU2, MDU3, MIC4
Target/Specificity This CD44 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 688-722 amino acids from the C-terminal region of human CD44.
Dilution WB~~1:1000
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD44 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD44
Synonyms LHR, MDU2, MDU3, MIC4
Function Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P15379}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15379}. Cell projection, microvillus {ECO:0000250|UniProtKB:P15379}. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250|UniProtKB:P15379}
Tissue Location Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas Expression is repressed in neuroblastoma cells
Research Areas
CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways.
Author : Ni SJ1,2,3,Zhao LQ1,2,Wang XF1,2,Wu ZH1,2,Hua RX1,2,Wan CH4,Zhang JY1,2,Zhang XW1,2,Huang MZ1,2,Gan L1,2,Sun HL5,Dimri GP6,Guo WJ7,8.
J Hematol Oncol. 2018 Feb 8;11(1):17. doi: 10.1186/s13045-018-0562-z.
29422082
Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress.
Author : Dong C1,2,Zhang L1,2,Sun R1,2,Liu J3,Yin H4,Li X5,Zheng X1,2,Zeng H1,2.
Sci Rep. 2016 Nov 15;6:36860. doi: 10.1038/srep36860.
27845427
The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.
Author : Li W1, Cohen A2, Sun Y3, Squires J4, Braas D5, Graeber TG6, Du L7, Li G7, Li Z8, Xu X9, Chen X4, Huang J10.
Mol Cancer Res. 2016 Apr;14(4):344-53. doi: 10.1158/1541-7786.MCR-15-0466. Epub 2016 Feb 1.
26832214
All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy.
Author : Yan Y1,2, Li Z3, Xu X3,4, Chen C3, Wei W1, Fan M5, Chen X3, Li JJ5, Wang Y6, Huang J3.
BMC Complement Altern Med. 2016 Mar 31;16(1):113. doi: 10.1186/s12906-016-1088-y.
27036550

BACKGROUND

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

REFERENCES

Stamenkovic I.,et al.Cell 56:1057-1062(1989).
Harn H.-J.,et al.Biochem. Biophys. Res. Commun. 178:1127-1134(1991).
Stamenkovic I.,et al.EMBO J. 10:343-348(1991).
Dougherty G.J.,et al.J. Exp. Med. 174:1-5(1991).
Kugelman L.C.,et al.J. Invest. Dermatol. 99:886-891(1992).

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