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GDF3 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GDF3 Antibody (Center) AP2066c
    Western blot analysis of anti-GDF3 Antibody (Center) (Cat.#AP2066c) in HepG2 cell line lysates (35ug/lane).GDF3 (arrow) was detected using the purified Pab.
  • 14 - GDF3 Antibody (Center) AP2066c
    Formalin-fixed and paraffin-embedded human testis tissue reacted with GDF3 antibody (Center) (Cat.#AP2066c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q9NR23
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41387 Da
Additional info
Gene ID 9573
Other Names Growth/differentiation factor 3, GDF-3, GDF3
Target/Specificity This GDF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-197 amino acids from the Central region of human GDF3.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGDF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF3
Function Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089).
Cellular Location Secreted. Cytoplasm Note=Mainly accumulated in the cytoplasm
Research Areas

BACKGROUND

GDF3 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. The function of this protein is unknown, but expression studies suggest it may be involved in regulation of the adult lymphatic and erythroid systems and embryonic development.

REFERENCES

Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).
Caricasole, A.A., et al., Oncogene 16(1):95-103 (1998).

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