|Application ||WB, IHC-P, E|
|Calculated MW||41387 Da|
|Other Names||Growth/differentiation factor 3, GDF-3, GDF3|
|Target/Specificity||This GDF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-197 amino acids from the Central region of human GDF3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GDF3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089).|
|Cellular Location||Secreted. Cytoplasm Note=Mainly accumulated in the cytoplasm|
GDF3 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. The function of this protein is unknown, but expression studies suggest it may be involved in regulation of the adult lymphatic and erythroid systems and embryonic development.
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).
Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).
Caricasole, A.A., et al., Oncogene 16(1):95-103 (1998).