|Application ||WB, E|
|Calculated MW||131868 Da|
|Other Names||Plakophilin-4, p0071, PKP4|
|Target/Specificity||This PKP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1040-1068 amino acids from the C-terminal region of human PKP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PKP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.|
|Cellular Location||Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells|
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
Hatzfeld M., et al. J. Cell Sci. 109:2767-2778(1996).
Hillier L.W., et al. Nature 434:724-731(2005).
Salomon A.R., et al. Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
Zhang Y., et al. Mol. Cell. Proteomics 4:1240-1250(2005).
Tao W.A., et al. Nat. Methods 2:591-598(2005).