|Application ||WB, IHC-P, E|
|Calculated MW||107113 Da|
|Other Names||MORC family CW-type zinc finger protein 3, Zinc finger CW-type coiled-coil domain protein 3, MORC3, KIAA0136, ZCWCC3|
|Target/Specificity||This MORC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 634-663 amino acids from the Central region of human MORC3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MORC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).|
|Cellular Location||Nucleus, nucleoplasm Nucleus matrix. Nucleus, PML body. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent|
|Tissue Location||Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney|
This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled coil domain.
Nagase T., et al. DNA Res. 2:167-174(1995).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Hattori M., et al. Nature 405:311-319(2000).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).