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MORC3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 14 - MORC3 Antibody (Center) AP20433c
    Immunohistochemical analysis of paraffin-embedded H. stomach section using MORC3 Antibody (Center)(Cat#AP20433c). AP20433c was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
  • 14 - MORC3 Antibody (Center) AP20433c
    Immunohistochemical analysis of paraffin-embedded H. kideny section using MORC3 Antibody (Center)(Cat#AP20433c). AP20433c was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
  • 1 - MORC3 Antibody (Center) AP20433c
    MORC3 Antibody (Center) (Cat. #AP20433c) western blot analysis in HL-60 and U87-MG cell line lysates (35ug/lane).This demonstrates the MORC3 antibody detected the MORC3 protein (arrow).
  • 14 - MORC3 Antibody (Center) AP20433c
    Formalin-fixed and paraffin-embedded H.placenta tissue reacted with MORC3 Antibody (Center) (Cat#AP20433c).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q14149
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 107113 Da
Additional info
Gene ID 23515
Other Names MORC family CW-type zinc finger protein 3, Zinc finger CW-type coiled-coil domain protein 3, MORC3, KIAA0136, ZCWCC3
Target/Specificity This MORC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 634-663 amino acids from the Central region of human MORC3.
Dilution IHC-P~~1:100
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMORC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MORC3 (HGNC:23572)
Function Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).
Cellular Location Nucleus, nucleoplasm Nucleus matrix. Nucleus, PML body. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent
Tissue Location Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney
Research Areas

BACKGROUND

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled coil domain.

REFERENCES

Nagase T., et al. DNA Res. 2:167-174(1995).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Hattori M., et al. Nature 405:311-319(2000).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).

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