|Application ||WB, IHC-P, E|
|Calculated MW||42203 Da|
|Other Names||Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, B3Gal-T8, Core 1 O-glycan T-synthase, Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1, 3-galactosyltransferase 1, Beta-1, 3-galactosyltransferase, Core 1 beta1, 3-galactosyltransferase 1, C1GalT1, Core 1 beta3-Gal-T1, C1GALT1|
|Target/Specificity||This C1GALT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-144 amino acids from the Central region of human C1GALT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C1GALT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Widely expressed. Highly expressed in kidney, heart, placenta and liver.|
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.
Ju T., et al. J. Biol. Chem. 277:178-186(2002).
Jensen M.P.A., et al. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Hillier L.W., et al. Nature 424:157-164(2003).
Scherer S.W., et al. Science 300:767-772(2003).
Ju T., et al. Proc. Natl. Acad. Sci. U.S.A. 99:16613-16618(2002).