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>   首页   >   产品   >   一抗   >   发育生物学   >   CSH1 Antibody (N-term)   

CSH1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CSH1 Antibody (N-term) AP20176a
    CSH1 Antibody (N-term) (Cat. #AP20176a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CSH1 antibody detected the CSH1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01243
Other Accession NP_072167.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Other Names CSH1; Chorionic somatomammotropin hormone; Lactogen; Placental lactogen
Target/Specificity This CSH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human CSH1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCSH1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq].

REFERENCES

Voorhees, J.L., et al. J. Biol. Chem. 285(26):20022-20030(2010)
Mannik, J., et al. J. Clin. Endocrinol. Metab. 95(5):2433-2442(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Varvarigou, A.A., et al. J Perinat Med 37(4):364-369(2009)
Chen, Y., et al. Cancer Res. 68(23):9729-9734(2008)

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