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UBE2S Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - UBE2S Antibody (C-term) AP20071b
    UBE2S Antibody (C-term) (Cat. #AP20071b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the UBE2S antibody detected the UBE2S protein (arrow).
  • 14 - UBE2S Antibody (C-term) AP20071b
    Formalin-fixed and paraffin-embedded H.adrenal tissue tissue reacted with UBE2S Antibody (C-term) (Cat#AP20071b).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q16763
Other Accession B5DFI8, Q921J4, Q1RML1, A1L3K1, NP_055316.2
Reactivity Human
Predicted Xenopus, Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23845 Da
Additional info
Gene ID 27338
Other Names Ubiquitin-conjugating enzyme E2 S, E2-EPF, Ubiquitin carrier protein S, Ubiquitin-conjugating enzyme E2-24 kDa, Ubiquitin-conjugating enzyme E2-EPF5, Ubiquitin-protein ligase S, UBE2S, E2EPF
Target/Specificity This UBE2S antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-210 amino acids from the C-terminal region of human UBE2S.
Dilution WB~~1:1000
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUBE2S Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2S
Synonyms E2EPF
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
Research Areas

BACKGROUND

This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins.

REFERENCES

Wu, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(4):1355-1360(2010)
Garnett, M.J., et al. Nat. Cell Biol. 11(11):1363-1369(2009)
Williamson, A., et al. Proc. Natl. Acad. Sci. U.S.A. 106(43):18213-18218(2009)
Chen, M.F., et al. J. Mol. Med. 87(3):307-320(2009)
Lim, J.H., et al. J. Cell. Biochem. 105(4):1117-1127(2008)

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