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BMPR1A Antibody (Center C180)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BMPR1A Antibody (Center C180) AP2004D
    Anti-BMPR1A Antibody (C180) at 1:2000 dilution + Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 60 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - BMPR1A Antibody (Center C180) AP2004D
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession P36894
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 657
Other Names Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3
Target/Specificity This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-195 amino acids from the Central region of human BMPR1A.
Dilution WB~~1:2000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBMPR1A Antibody (Center C180) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMPR1A
Synonyms ACVRLK3, ALK3
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein. Cell surface {ECO:0000250|UniProtKB:P36895}
Tissue Location Highly expressed in skeletal muscle.
Research Areas
The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition.
Author : Zhang C1, Feng Y, Yang H, Koga H, Teitelbaum DH.
J Nutr. 2009 Jul;139(7):1315-21. doi: 10.3945/jn.108.096669. Epub 2009 Jun 4.
19498022

BACKGROUND

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

REFERENCES

Zhou, X.-P., et al., Am. J. Hum. Genet. 69(4):704-711 (2001).
Howe, J.R., et al., Nat. Genet. 28(2):184-187 (2001).
ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).

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