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SYNJ2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SYNJ2 Antibody (Center) AP19970c
    SYNJ2 Antibody (Center) (Cat. #AP19970c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the SYNJ2 antibody detected the SYNJ2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O15056
Other Accession NP_003889.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 165538 Da
Additional info
Gene ID 8871
Other Names Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348
Target/Specificity This SYNJ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 679-707 amino acids from the Central region of human SYNJ2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYNJ2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNJ2
Synonyms KIAA0348
Function Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Cellular Location Cytoplasm. Cell membrane. Membrane raft. Cell projection, axon {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at nerve terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340)
Research Areas

BACKGROUND

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.

REFERENCES

Rikova, K., et al. Cell 131(6):1190-1203(2007)
Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)
Rossi, M.R., et al. Cancer Genet. Cytogenet. 161(2):97-103(2005)
Chuang, Y.Y., et al. Cancer Res. 64(22):8271-8275(2004)
Spaenij-Dekking, E.H., et al. Leukemia 17(12):2467-2473(2003)

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