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>   首页   >   产品   >   一抗   >   其他   >   HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody(C-term)   

HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody(C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody(C-term) AP19790b
    HIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody (C-term) (Cat. #AP19790b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the HIST1H2BJ/HIST1H2BK/HIST3H2BB antibody detected the HIST1H2BJ/HIST1H2BK/HIST3H2BB protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P06899
Other Accession P57053, Q64524, Q8CGP1, Q2PFX4, O60814, Q2M2T1, P06900, P02281, NP_066402.2
Reactivity Human
Predicted Xenopus, Bovine, Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 13904 Da
Additional info
Gene ID 8970
Other Names Histone H2B type 1-J, Histone H2B1, Histone H2Br, H2B/r, HIST1H2BJ, H2BFR
Target/Specificity This HIST1H2BJ/HIST1H2BK/HIST3H2BB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the C-terminal region of human HIST1H2BJ/HIST1H2BK/HIST3H2BB.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHIST1H2BJ/HIST1H2BK/HIST3H2BB Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HIST1H2BJ
Synonyms H2BFR
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Research Areas
Mass spectrometry-based proteomic analysis reveals the interacting partners of lipin1.
Author : Wang J1,Wang S1,Yan C1,Deng Y2,Huang Z2,Shi P1.
IUBMB Life. 2018 Aug 9. doi: 10.1002/iub.1873. [Epub ahead of print]
30092116

BACKGROUND

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq].

REFERENCES

Shi, J., et al. Nature 460(7256):753-757(2009)
Benyamin, B., et al. Am. J. Hum. Genet. 84(1):60-65(2009)
Kim, S.C., et al. Mol. Cell 23(4):607-618(2006)
Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006)
Pavri, R., et al. Cell 125(4):703-717(2006)

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