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>   首页   >   产品   >   一抗   >   细胞生物学   >   Mouse Senp1 Antibody(Center)   

Mouse Senp1 Antibody(Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Mouse Senp1 Antibody(Center) AP19695c
    Mouse Senp1 Antibody (Center) (Cat. #AP19695c) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Mouse Senp1 antibody detected the Mouse Senp1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P59110
Other Accession NP_659100.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 72511 Da
Additional info
Gene ID 223870
Other Names Sentrin-specific protease 1, SUMO-1 protease 2, SuPr-2, Sentrin/SUMO-specific protease SENP1, Senp1, Supr2
Target/Specificity This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Senp1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Senp1
Synonyms Supr2
Function Protease that catalyzes two essential functions in the SUMO pathway (PubMed:15923632, PubMed:29499132). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (By similarity). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Deconjugates SUMO1 from METTL3 (By similarity). Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity). Deconjugates SUMO1 from GPS2 (PubMed:29499132).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q9P0U3}. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Research Areas

BACKGROUND

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.

REFERENCES

Bawa-Khalfe, T., et al. J. Biol. Chem. 285(33):25859-25866(2010)
Yu, L., et al. J. Exp. Med. 207(6):1183-1195(2010)
Sharma, P., et al. J. Cell. Sci. 123 (PT 8), 1227-1234 (2010) :
Li, X., et al. Cell Death Differ. 15(4):739-750(2008)
Cheng, J., et al. Cell 131(3):584-595(2007)

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