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BRAP Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BRAP Antibody(N-term) AP19664a
    BRAP Antibody (N-term) (Cat. #AP19664a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the BRAP antibody detected the BRAP protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q7Z569
Other Accession NP_006759.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67305 Da
Additional info
Gene ID 8315
Other Names BRCA1-associated protein, 632-, BRAP2, Impedes mitogenic signal propagation, IMP, RING finger protein 52, Renal carcinoma antigen NY-REN-63, BRAP (HGNC:1099), RNF52
Target/Specificity This BRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human BRAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBRAP Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRAP (HGNC:1099)
Synonyms RNF52
Function Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Cellular Location Cytoplasm.
Tissue Location Expressed in breast epithelial cell lines.
Research Areas

BACKGROUND

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.

REFERENCES

Fulcher, A.J., et al. FASEB J. 24(5):1454-1466(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
Hinohara, K., et al. J. Hum. Genet. 54(11):642-646(2009)
Cui, R., et al. Gastroenterology 137(5):1768-1775(2009)

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