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TIPIN Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - TIPIN Antibody(N-term) AP19596a
    TIPIN Antibody (N-term) (Cat. #AP19596a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TIPIN antibody detected the TIPIN protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9BVW5
Other Accession NP_060328.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 34555 Da
Additional info
Gene ID 54962
Other Names TIMELESS-interacting protein, TIPIN
Target/Specificity This TIPIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the N-terminal region of human TIPIN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTIPIN Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIPIN
Function Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
Cellular Location Cytoplasm. Nucleus
Research Areas

BACKGROUND

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.

REFERENCES

Kemp, M.G., et al. J. Biol. Chem. 285(22):16562-16571(2010)
Leman, A.R., et al. J. Cell. Sci. 123 (PT 5), 660-670 (2010) :
Utge, S.J., et al. PLoS ONE 5 (2), E9259 (2010) :
Unsal-Kacmaz, K., et al. Mol. Cell. Biol. 27(8):3131-3142(2007)
Gotter, A.L., et al. J. Mol. Biol. 366(1):36-52(2007)

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