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GSTT2 Antibody(Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GSTT2 Antibody(Center) AP19567c
    GSTT2 Antibody (Center) (Cat. #AP19567c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GSTT2 antibody detected the GSTT2 protein (arrow).
  • 14 - GSTT2 Antibody(Center) AP19567c
    Formalin-fixed and paraffin-embedded H.adrenal tissue tissue reacted with GSTT2 Antibody(Center) (Cat#AP19567c).
  • 14 - GSTT2 Antibody(Center) AP19567c
    Formalin-fixed and paraffin-embedded H.liver tissue reacted with GSTT2 Antibody(Center) (Cat#AP19567c).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P0CG29
Other Accession P0CG30, NP_000845.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 2953
Other Names Glutathione S-transferase theta-2, GST class-theta-2, GSTT2
Target/Specificity This GSTT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the Central region of human GSTT2.
Dilution WB~~1:1000
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGSTT2 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSTT2
Function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
Cellular Location Cytoplasm.
Tissue Location Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells
Research Areas

BACKGROUND

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

REFERENCES

Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)
Canova, C., et al. Tumori 96(1):1-10(2010)
Wang, S., et al. Ann. Hum. Genet. 74(1):46-56(2010)
Gemignani, F., et al. Mutat. Res. 671 (1-2), 76-83 (2009) :
Tatemichi, M., et al. J. Hum. Genet. 54(10):557-563(2009)

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