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>   首页   >   产品   >   一抗   >   信号转导   >   ATP6V1G1 Antibody(C-term)   

ATP6V1G1 Antibody(C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ATP6V1G1 Antibody(C-term) AP19555b
    ATP6V1G1 Antibody (C-term) (Cat. #AP19555b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ATP6V1G1 antibody detected the ATP6V1G1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O75348
Other Accession Q9CR51, P79251, NP_004879.1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 13758 Da
Additional info
Gene ID 9550
Other Names V-type proton ATPase subunit G 1, V-ATPase subunit G 1, V-ATPase 13 kDa subunit 1, Vacuolar proton pump subunit G 1, Vacuolar proton pump subunit M16, ATP6V1G1, ATP6G, ATP6G1, ATP6J
Target/Specificity This ATP6V1G1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the C-terminal region of human ATP6V1G1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsATP6V1G1 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP6V1G1
Synonyms ATP6G, ATP6G1, ATP6J
Function Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
Tissue Location Ubiquitous..
Research Areas

BACKGROUND

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.

REFERENCES

Norgett, E.E., et al. J. Biol. Chem. 282(19):14421-14427(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Morel, N. Biol. Cell 95(7):453-457(2003)
Smith, A.N., et al. Mol. Cell 12(4):801-803(2003)

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