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AQP3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - AQP3 Antibody (Center) AP19289c
    AQP3 Antibody (Center)(Cat. #AP19289c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).
  • 1 - AQP3 Antibody (Center) AP19289c
    AQP3 Antibody (Center) (Cat. #AP19289c) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AQP3 antibody detected the AQP3 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q92482
Other Accession P47862, Q8R2N1, Q08DE6, NP_004916.1
Reactivity Human, Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31544 Da
Additional info
Gene ID 360
Other Names Aquaporin-3, AQP-3, Aquaglyceroporin-3, AQP3
Target/Specificity This AQP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human AQP3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAQP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP3
Function Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Cellular Location Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney
Tissue Location Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level
Research Areas

BACKGROUND

Aquaporin 3 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, N.H., et al. J. Invest. Dermatol. 130(9):2231-2239(2010)
Ji, C., et al. Int. J. Mol. Med. 26(2):257-263(2010)
Melis, M., et al. Dis. Colon Rectum 53(6):936-943(2010)
Shen, L., et al. Biomed. Pharmacother. 64(5):313-318(2010)

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