|Application ||WB, E|
|Calculated MW||61640 Da|
|Other Names||Far upstream element-binding protein 3, FUSE-binding protein 3, FUBP3, FBP3|
|Target/Specificity||This FUBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-67 amino acids from the N-terminal region of human FUBP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FUBP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression.|
|Tissue Location||Detected in a number of cell lines.|
Provided below are standard protocols that you may find useful for product applications.
The far upstream element-binding proteins FUBP, FUBP2, and FUBP3 comprise a family of single-strand DNA-binding proteins that possess all of the general features of more conventional transcription factors. The FUBPs each bind to a single sequence-specific strand of the far upstream element (FUSE; originally identified upstream of c-myc), and each possesses potent activation domains when fused to the GAL4 DNA-binding domain and assayed by transient transfection. These proteins have also been reported to bind RNA and participate in various steps of RNA processing, transport or catabolism.
He L, et al. Nucleic Acids Res. 2000 Nov 15;28(22):4558-65.
Davis-Smyth T, et al. J Biol Chem. 1996 Dec 6;271(49):31679-87.