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Erythropoietin Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Erythropoietin Antibody AP18527a
    All lanes : Anti-Erythropoietin Antibody at 1:500 dilution Lane 1: Human liver lysate Lane 2: HepG2 whole cell lysate Lane 3: Mouse kidney lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 21 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01588
Other Accession NP_000790
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21307 Da
Additional info
Gene ID 2056
Other Names Erythropoietin, Epoetin, EPO
Target/Specificity This EPO antibody is generated from rabbits immunized with a recombinant protein of human EPO.
Dilution WB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsErythropoietin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPO
Function Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
Cellular Location Secreted.
Tissue Location Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals
Research Areas

BACKGROUND

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq].

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kristensen, P.L., et al. Eur. J. Endocrinol. 163(3):391-398(2010)
Kim, M.H., et al. Mol. Biol. (Mosk.) 44(4):656-663(2010)
Carraway, M.S., et al. Circ. Res. 106(11):1722-1730(2010)
Shi, Z., et al. Mol. Cancer Res. 8(4):615-626(2010)

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