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>   首页   >   产品   >   一抗   >   细胞生物学   >   FBXL19 Antibody (C-term)   

FBXL19 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FBXL19 Antibody (C-term) AP18447b
    Anti-FBXL19 Antibody (C-term) at 1:2000 dilution + A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 76 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q6PCT2
Other Accession Q6PB97, NP_001093254.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 75707 Da
Additional info
Gene ID 54620
Other Names F-box/LRR-repeat protein 19, F-box and leucine-rich repeat protein 19, FBXL19, FBL19
Target/Specificity This FBXL19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-570 amino acids from the C-terminal region of human FBXL19.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXL19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXL19
Synonyms FBL19
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.
Research Areas
Histone acetyltransferase CBP promotes function of SCF FBXL19 ubiquitin E3 ligase by acetylation and stabilization of its F-box protein subunit.
Author : Wei J1,Dong S1,2,Yao K1,Martinez MFYM1,Fleisher PR1,Zhao Y1,Ma H2,Zhao J1.
FASEB J. 2018 Mar 9:fj201701069R. doi: 10.1096/fj.201701069R. [Epub ahead of print]
29522376
SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation.
Author : Zhao J1, Mialki RK, Wei J, Coon TA, Zou C, Chen BB, Mallampalli RK, Zhao Y.
FASEB J. 2013 Jul;27(7):2611-9. doi: 10.1096/fj.12-223099. Epub 2013 Mar 19.
23512198

BACKGROUND

Members of the F-box protein family, such as FBXL19, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

REFERENCES

Martin, J., et al. Nature 432(7020):988-994(2004)
Katoh, M., et al. Int. J. Mol. Med. 14(6):1109-1114(2004)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)

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