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PPFIBP1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PPFIBP1 Antibody (Center) AP17453c
    All lanes : Anti-PPFIBP1 Antibody (Center) at 1:2000 dilution Lane 1: HepG2 whole cell lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 114 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - PPFIBP1 Antibody (Center) AP17453c
    Formalin-fixed and paraffin-embedded H.adrenal tissue tissue reacted with PPFIBP1 Antibody (Center) (Cat#AP17453c).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q86W92
Other Accession Q8C8U0, NP_003613.2, NP_803193.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 114024 Da
Additional info
Gene ID 8496
Other Names Liprin-beta-1, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1, PTPRF-interacting protein-binding protein 1, hSGT2, PPFIBP1, KIAA1230
Target/Specificity This PPFIBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-617 amino acids from the Central region of human PPFIBP1.
Dilution WB~~1:2000
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPFIBP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPFIBP1
Synonyms KIAA1230
Function May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
Tissue Location Widely expressed. Absent in liver.
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

REFERENCES

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Norrmen, C., et al. Blood 115(4):906-909(2010)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)

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