|Application ||WB, E|
|Other Accession||Q8CD54, NP_071351.2|
|Other Names||Piezo-type mechanosensitive ion channel component 2, Protein FAM38B, PIEZO2, C18orf30, C18orf58, FAM38B|
|Target/Specificity||This FAM38B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2575-2604 amino acids from the N-terminal region of human FAM38B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAM38B Antibody-(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C18orf30, C18orf58, FAM38B|
|Function||Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light- touch mechanosensation.|
|Cellular Location||Membrane; Multi-pass membrane protein|
Provided below are standard protocols that you may find useful for product applications.
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons (Coste et al., 2010 [PubMed 20813920]).
Coste, B., et al. Science 330(6000):55-60(2010)
Brandenberger, R., et al. Nat. Biotechnol. 22(6):707-716(2004)