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TRAPPC2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - TRAPPC2 Antibody (N-term) AP16270a
    TRAPPC2 Antibody (N-term) (Cat. #AP16270a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TRAPPC2 antibody detected the TRAPPC2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P0DI81
Other Accession F1SRI0, Q9CQP2, Q08CN0, Q5ZKP4, Q3T0F2, P0DI82
Reactivity Human
Predicted Bovine, Chicken, Zebrafish, Mouse, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 16445 Da
Additional info
Gene ID 6399
Other Names Trafficking protein particle complex subunit 2, Sedlin, TRAPPC2, SEDL
Target/Specificity This TRAPPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human TRAPPC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRAPPC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRAPPC2
Synonyms SEDL
Function Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Cellular Location Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Localized in perinuclear granular structures
Tissue Location Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes
Research Areas

BACKGROUND

TRAPPC2 is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y.

REFERENCES

Liu, X., et al. J. Cell. Biochem. 109(6):1129-1133(2010)
Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :
Xia, X.Y., et al. Clin. Chim. Acta 410 (1-2), 39-42 (2009) :
Guo, H., et al. J. Genet. 88(1):87-91(2009)
Xiong, F., et al. Eur. J. Hum. Genet. 17(4):510-516(2009)

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