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>   首页   >   产品   >   一抗   >   癌症   >   GATE16 Antibody (N-term)   

GATE16 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GATE16 Antibody (N-term) AP16026a
    GATE16 Antibody (N-term) (Cat. #AP16026a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GATE16 antibody detected the GATE16 protein (arrow).
  • 1 - GATE16 Antibody (N-term) AP16026a
    GATE16 Antibody (N-term) (Cat. #AP16026a) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the GATE16 antibody detected the GATE16 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P60520
Other Accession P60522, P60521, P60519, NP_009216.1
Reactivity Human, Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 13667 Da
Additional info
Gene ID 11345
Other Names Gamma-aminobutyric acid receptor-associated protein-like 2, GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, GEF-2, General protein transport factor p16, Golgi-associated ATPase enhancer of 16 kDa, GATE-16, MAP1 light chain 3-related protein, GABARAPL2, FLC3A, GEF2
Target/Specificity This GATE16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-28 amino acids from the N-terminal region of human GATE16.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGATE16 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABARAPL2
Synonyms FLC3A, GEF2
Function Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Cellular Location Golgi apparatus. Cytoplasmic vesicle, autophagosome
Tissue Location Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle Expressed at very low levels in lung, thymus and small intestine
Research Areas

BACKGROUND

Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity).

REFERENCES

Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Dastani, Z., et al. Eur. J. Hum. Genet. 18(3):342-347(2010)
Thielmann, Y., et al. Proteins 77(3):637-646(2009)
Kirkin, V., et al. Mol. Cell 33(4):505-516(2009)
Shvets, E., et al. Autophagy 4(8):1054-1056(2008)

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