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VILIP1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - VILIP1 Antibody (C-term) AP1561A
    Western blot analysis of lysates from human brain, mouse brain, rat brain and rat eyeball tissue lysate (from left to right), using VILIP1 Antibody (C-term)(Cat. #AP1561a). AP1561a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • 1 - VILIP1 Antibody (C-term) AP1561A
    Western blot analysis of lysates from SW480 cell line, human brain, mouse brain and rat brain tissue lysate(from left to right), using VILIP1 Antibody (C-term)(Cat. #AP1561a). AP1561a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • 14 - VILIP1 Antibody (C-term) AP1561A
    Formalin-fixed and paraffin-embedded human brain tissue reacted with VILIP1 antibody (C-term ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 14 - VILIP1 Antibody (C-term) AP1561A
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with VILIP1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession P62760
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 7447
Other Names Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1
Target/Specificity This VILIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-150 amino acids from the C-terminal region of human VILIP1.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVILIP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VSNL1
Synonyms VISL1
Function Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.
Tissue Location Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).
Research Areas
Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington's disease.
Author : López-Hurtado A1,2,Burgos DF1,2,González P1,2,Dopazo XM1,2,González V1,3,Rábano A1,3,Mellström B1,2,Naranjo JR4,5.
Mol Brain. 2018 Mar 9;11(1):13. doi: 10.1186/s13041-018-0359-6.
29523177
Proteomics analysis of the temporal changes in axonal proteins during maturation.
Author : Yamatani H, Kawasaki T, Mita S, Inagaki N, Hirata T.
Dev Neurobiol. 2010 Jun;70(7):523-37. doi: 10.1002/dneu.20794.
20225247

BACKGROUND

The visinin and visinin-like peptides represent a family of calcium-binding proteins that are highly expressed in the retina. Visinin has been shown to be a cone cell-specific protein with a molecular weight of 24 kDa. Several members of the visinin family of genes have been isolated and characterized from different species. These peptides are believed to be involved in the processes of phototransduction. The recoverin gene (RCV1) is believed to be involved in the pathophysiology of retinopathy in cancer patients.

REFERENCES

Braunewell, K.H., et al., Neuropharmacology 44(6):707-715 (2003). Lin, L., et al., J. Biol. Chem. 277(44):41872-41878 (2002). Spilker, C., et al., J. Neurosci. 22(17):7331-7339 (2002). Bernstein, H.G., et al., Neuroreport 13(4):393-396 (2002). Lin, L., et al., Biochem. Biophys. Res. Commun. 296(4):827-832 (2002).

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