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KRT7 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - KRT7 Antibody (N-term) AP14897a
    KRT7 Antibody (N-term) (Cat. #AP14897a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KRT7 antibody detected the KRT7 protein (arrow).
  • 14 - KRT7 Antibody (N-term) AP14897a
    KRT7 Antibody (N-term) (AP14897a)immunohistochemistry analysis in formalin fixed and paraffin embedded human bladder carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KRT7 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P08729
Other Accession NP_005547.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51386 Da
Additional info
Gene ID 3855
Other Names Keratin, type II cytoskeletal 7, Cytokeratin-7, CK-7, Keratin-7, K7, Sarcolectin, Type-II keratin Kb7, KRT7, SCL
Target/Specificity This KRT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the N-terminal region of human KRT7.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKRT7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT7
Synonyms SCL
Function Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Cellular Location Cytoplasm.
Tissue Location Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus
Research Areas
N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy.
Author : Deng Q1, Chen Y1, Yin N1, Shan N1, Luo X1, Tong C1, Zhang H1, Baker PN2, Liu X3, Qi H4.
Placenta. 2015 Sep 1. pii: S0143-4004(15)30041-2. doi: 10.1016/j.placenta.2015.08.014. [Epub ahead of print]
26349781

BACKGROUND

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.

REFERENCES

Tsai, Y.Y., et al. Acta Derm. Venereol. 90(4):438-439(2010)
Stewart, C.J., et al. Histopathology 57(1):46-54(2010)
Nagashio, R., et al. Pathol. Int. 60(2):71-77(2010)
Sano, M., et al. Int. J. Oncol. 36(2):321-330(2010)
Park, S., et al. Pathology 41(7):640-644(2009)

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