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CRABP2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CRABP2 Antibody (C-term) AP14756b
    CRABP2 Antibody (C-term) (Cat. #AP14756b) western blot analysis MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CRABP2 antibody detected the CRABP2 protein (arrow).
  • 1 - CRABP2 Antibody (C-term) AP14756b
    Western blot analysis of CRABP2 (arrow) using rabbit polyclonal CRABP2 Antibody (C-term) (Cat. #AP14756b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRABP2 gene.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P29373
Other Accession Q5PXY7, NP_001869.1
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 15693 Da
Additional info
Gene ID 1382
Other Names Cellular retinoic acid-binding protein 2, Cellular retinoic acid-binding protein II, CRABP-II, CRABP2
Target/Specificity This CRABP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 amino acids from the C-terminal region of human CRABP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCRABP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CRABP2
Function Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Cellular Location Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus
Research Areas

BACKGROUND

A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The inducibility of the CRABP2 gene suggests that this isoform is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein. [provided by RefSeq].

REFERENCES

Sola, R., et al. Atherosclerosis 211(2):630-637(2010) Manolescu, D.C., et al. Pediatr. Res. 67(6):598-602(2010) Calmon, M.F., et al. Neoplasia 11(12):1329-1339(2009) Corlazzoli, F., et al. PLoS ONE 4 (1), E4305 (2009) : Gupta, A., et al. Exp. Cell Res. 314(20):3663-3668(2008)

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